CORTAVANCE® : A Topical Hydrocortisone Aceponate (HCA) Spray
A topical corticoid that is used for symptomatic treatment of inflammatory and pruritic dermatoses in dogs.
Dog
CORTAVANCE®is a topical glucocorticoid providing effective and targeted treatment. It is rapidly absorbed into the stratum corneum and metabolized into an inactive metabolite. This means there can be none of the side effects associated with traditional corticosteroids.
Hydrocortisone aceponate (HCA) is safe and well-tolerated.
No systemic effects
No effect on behaviour or on food intake
No effect on blood chemistry
No alteration of the immune system
No suppression of the HPA axis
No atrophy of the skin
Safe to the pet owner
Composition: 1 ml of Cortavance contains 0.584mg of hydrocortisone aceponate in propylene glycol methyl ether
Pack Sizes: 31ml and 76ml
Properties: After topical application, Cortavance inhibits inflammatory and allergic reactions in dog's skin, leading to the regression of pruritis and associated lesions (erythema, excoriations, lichenification, self-induced alopecia). Hydrocortisone aceponate (HCA) belongs to the non-halogenated diester family of topical glucocorticoids that feature unique pharmacokinetic properties: rapid penetration in skin (high lipophilicity), activation in the epidermis (targeted high anti-inflammatory potency), subsequent transformation to weaker metabolites in the lower epidermis and dermis that are quickly inactivated in the blood stream (negligible systemic effects).
Indication: For symptomatic treatment of pruritic inflammatory skin disease in dogs
Dosage and directions for use: Before the first administration, screw the pump spray on the bottle.
Dosage: 2 pumps per 100cm2 (palm of the human's hand) of diseased skin surface. Spray 10cm away from the body surface. No massage is required. Cover eyes when spraying on the animal's face (Figure 1)
Regimen: Once a day for 7 consecutive days. Treatment over a longer period of time is subject to the veterinarian's appreciation of the benefit-risk.
As a general rule, the duration of use should be kept as brief as possible in the treatment of large skin areas. Do not apply other topical preparations simultaneously on the same lesions.
Figure 1: Two sprays over a surface area of 10 x 10cm for 7 consecutive days or as determined as necessary (maximum of 70 days)
Precautions: Concurrent microbial or parasitic disease should receive a specific curative treatment. The use in young dogs (<7 months), animals suffering from Cushing's disease and pregnant, lactating bitches is subject to the veterinarian's appreciation of the benefit-risk. They do not represent formal contraindications since the systemic absorption (bioavailability) of hydrocortisone aceponate is negligible.
User Safety: Spray in well-ventilated areas and away from a naked flame. Wash hands after use. In case of accidental skin contact, wash thoroughly with water. In case of eye irritation, rinse thoroughly with water and seek medical advice where needed.
Storage: Shelf life: 2 years in intact commercial package, 6 months after the first opening. No particular storage conditions are required. Keep out of reach of children.
HOW OPTIMIZE THE CHOICE BETWEEN THE 76ML AND THE 31ML?
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