Biologics

SHOTAPEN® LA Pencillin-Streptomycin RTU Injectable Solution

Shotapen LA® : A Long-Acting Antibiotic Duo Pencillin-Streptomycin Injectable Solution

  • Swine

WHAT IS SHOTAPEN® LA?

Shotapen® LA is an injectable, long-acting suspension containing two antibiotics, Benzyl penicillin and Dihyydrostreptomycin. Benzyl penicillin is present in two forms:

  • Benzyl penicillin in procaine monohydrate form produces quick and immediate effects 18-24 hours after injection.
  • Benzyl penicillin in the form of benzathine has a slow effect, lasting over 3 days.

Dihydrostreptomycin has a rapid bactericidal effect in the first few hours after injection, and a long-lasting bacteriostatic proliferation for 72 hours.

The above combination gives Shotapen® LA a broad and effective spectrum of action on Gram(+) and Gram(-) bacteria.

 

WHY CHOOSE SHOTAPEN® LA?

  • Broad antibacterial spectrum
  • Effective treatment
  • The effects last 72 hours

 

INGREDIENT

Each 1ml contains:

  • Benzylpenicillin (benzathine form) .............................. 73.58mg
  • Benzylpenicillin (procaine monohydrate form) .............. 56.80mg
  • Dihydrostreptomycin (sulfate form) ............................ 164mg
  • Sufficient excipients ................................................. 1ml

 

DOSAGE AND INSTRUCTIONS FOR USE

Used for pigs, cows, dogs, cats, and intramuscular injection:

  • Pigs and cows: 1ml/10kg body weight, give a single injection every 72 hours
  • Calves, piglets, and small animals: 1 -2 ml/25 kg body weight, for a single injection every 72 hours

Intramuscularly or subcutaneously, at a dose of 1ml of the drug per 10kg of body weight once. In severe cases, re-administration of the drug is recommended after 3 days.

For severe cases, the injection can be repeated after 3 days. Treatment must continue for at least 48 hours after symptoms disappear.

 

INDICATIONS

Treatment of infections of bacterial origin caused by microorganisms sensitive to penicillin and dihydrostreptomycin in cattle and horses.

 

CONTRAINDICATIONS/PRECAUTIONS

Increased sensitivity to penicillin and dihydrostreptomycin. Do not use simultaneously with other antibiotics containing antagonism (gentamicin or Kanamycine).

  • Do not use the intravenous route.
  • Do not administer to animals hypersensitive to penicillin.
  • Do not apply has apply needs the dosage of the product to avoid retention of dihydrostreptomycin

 

PHARMOKINETICS

Shotapen® LA is a ready-to-use injectable preparation that combines the benzylpenicillins procaine and benzathine with dihydrostreptomycin, which gives the product not only a broad spectrum, but also a prolonged period of action.

Procaine and benzathine benzylpenicillins are potent antibiotics from the Beta-lactam family that act by inhibiting the synthesis of the bacterial cell wall through interference with the transpeptidase enzyme.

Penicillin is a highly active against Gram-positive microorganisms - both aerobic and anaerobic such as Staphylococcus spp., Streptococcus spp., Corynebacterium diphtheriae, and others. 

Dihydrostreptomycin is an aminoglycoside antibiotic that acts bactericidal to gram-negative and gram-positive microorganisms (Pasteurella spp., Salmonella spp., E.coli., Klebsiella spp., Haemophilus spp., Brucella spp., Shigella spp., Mycobacterium spp.)

 

WITHDRAWAL PERIOD

Slaughter of animals for meat is allowed respectively in 35 days (pigs) and 49 days (cattle). 

 

STORAGE

Keep in a dry, dark place inaccessible for children at temperatures of 10 °C up to 25 °C.

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